赵云飞,苏 娟

这篇综述系统探讨了间充质干细胞在治疗高原性痛风中的研究进展。高原环境通过持续低氧影响尿酸代谢，导致高尿酸血症和痛风发病率升高，传统药物治疗在高海拔条件下存在疗效受限、副作用增加及无法实现组织修复等问题。间充质干细胞凭借其抗炎、免疫调节、促进组织修复和调节尿酸代谢等多重功能，展现出治疗潜力。文章重点阐述了缺氧诱导因子在高原痛风发病机制中的作用，及其与间充质干细胞功能的相互作用，提出了通过低氧预处理等策略优化间充质干细胞治疗效果的新思路。尽管面临安全性、标准化和临床转化等挑战，间充质干细胞疗法仍有望成为高原痛风治疗的重要突破。

高原性痛风；间充质干细胞；缺氧诱导因子；尿酸代谢；组织修复；低氧预处理；MSCs疗法

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