刘春丽,宋素珍,黄冬梅,蒋宝玉,刘 维

目的：探讨早产儿发生早发性低钙血症（EOH）的影响因素。方法：利用中国医院药物警戒系统（CHPS）收集2019年1月至2024年12月在广西科技大学第一附属医院分娩的早产儿及其母亲的临床资料，根据是否发生早发性低钙血症（EOH）分为研究组和对照组。采用单因素分析和多因素logistic回归模型筛选影响因素。结果：通过CHPS检索共纳入早产儿199例，51例发生了EOH，EOH发生率为25.63%。多因素回归分析表明，母亲妊娠期糖尿病（OR=4.486，95%CI：1.843～10.918）、剖宫产（OR=2.455，95%CI：1.012～5.956）、分娩前7天内硫酸镁连续使用时长（OR=1.408，95%CI：1.003～1.978）、妊娠期利托君日均暴露量（OR=1.007，95%CI：1.002～1.012）是EOH的独立危险因素（P<0.05），而妊娠期利托君使用时长（OR=0.919，95%CI：0.864～0.979）为保护因素（P<0.05）。结论：临床应关注母亲妊娠期糖尿病、剖宫产、硫酸镁及利托君使用情况，早期监测新生儿血钙水平，降低EOH风险。

早产儿；早发性低钙血症；影响因素；硫酸镁；利托君

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